The instability and high reactivity of Fe 2+ lead to the generation of hydroxyl radicals from excess iron by means of the Fenton reaction
10.1002/ijc.30543 339 LevingstonCAYoungMRI
The system is a disulfide-link heterodimer consisting of SLC7A11 (xCT) and regulatory subunit SLC3A2 (4F2hc and CD98hc) ( in vitro , the import of cystine via system is significant for maintaining the levels of Cys and GSH, and preventing ferroptosis (Figure 2D), a potent inducer of ferroptosis, is a specific inhibitor of the system ( subunit Slc7a11 in mice induces ferroptosis and inhibits the growth of pancreatic ductal adenocarcinoma (Figure 2D) can induce ferroptosis in retinal pigment epithelium by inhibiting glutamate-cysteine ligase (GCL), a rate-limiting enzyme in de novo GSH synthesis ( CoQ 10 -dependent Pathway However, the responses of GPX4 inhibitors in different cell lines are not consistent (Zou et al., 2019), indicating that there may be pathways independent of GPX4 to regulate ferroptosis
DNA methylation is not impervious to external conditions
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