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Inhibition of NF-kappa B binding to DNA by chromium, cadmium, mercury, zinc, and arsenite in vitro : evidence of a thiol mechanism Arch Biochem Biophys 1998 349 : 356362 Yang JP, Merin JP, Nakano T, Kato T, Kitade Y, Okamoto T

Thus, p53 enhances the expression of GLS2 and promotes the conversion of glutamate to -ketoglutarate, which increases the production of lipid reactive oxygen species so that induce ferroptosis

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By contrast, extracellular degrading enzyme produces cysteine, providing an additional rate-limiting amino acid for resynthesis of intracellular GSH (16)

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