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This direct contact may enhance local tissue effects beyond what systemic administration achieves

We observed a pronounced vehicle-corrected weight loss of 15.2% in the group treated with GLP-1MK-801 compared with 3.5% in the group treated with the parent GLP-1 analogue after 9 days of treatment, underscoring that the weight-lowering efficacy of the conjugate is intact in the absence of functional MC4R signalling (Fig

Barger G & Ewins AJ (1911) CCLVII

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The Trp161Phe variant has historically been puzzling as it profoundly affects PCET catalysis without directly removing a hydrogen bond donor or acceptor 26,48,51