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DPP-4i could restore the inactivation of AKT and ERK signaling and inhibit NF-B activation to reduce the production of pro-inflammatory factors, including TNF-, IL-1, monocyte chemoattractant protein-1 (MCP-1), ICAM-1 and TGF- (169, 170)

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Seven metabolites (norscopine, scopine, tropic acid, aponorscopolamine, aposcopolamine, norscopolamine, and hydroxyscopolamine) and the parent drug are detected in rat plasma