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Supple- begin to bleed, the skin becomes hyperkera- menting dietary calcium intake during ado- totic, rough, and dry, and capillary hemor- lescence and adulthood reduces turnover of rhages appear in the skin.9 In contrast, margi- bone and promotes mineral deposition into nal nutrient deficiencies only gradually im- the skeleton14,15

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Additionally, the Schlafen family of proteins (SLFN11) controls cell proliferation and induces immune responses [150]

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doi: 10.1016/S1054-139X(02)00349-X 92