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Melatonin is often referred to as the body's "sleep hormone," though it is more accurately described as a circadian signaling molecule that helps synchronize the sleep-wake cycle with environmental light and darkness and promotes sleep onset partly by lowering core body temperature

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However, the use of any medication or supplement should be done under the guidance of a healthcare professional, as they can provide personalized advice based on health needs and considerations

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Indeed, computer model simulations demonstrate that weight-dependent heterosynaptic plasticity can robustly prevent runaway dynamics of synaptic weights and runaway activity of model neurons subject to widely different patterns of activity and equipped with widely different plasticity rules (Chen et al., 2016