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Vitamin B12 in cancer development Most of the evidence does not absolutely clarify the role of vitamin B12 in the process of carcinogenesis and anticancer defense

60 The Km of the human NNMT enzyme for NAM (approximately 430 M) is much higher than the affinity of NAMPT for NAM ( 0.1 mM in mammalian plasma, which can only be used by spleen, small intestine, pancreas, kidney and liver

However, its important to note that many doctors rule out B12 deficiency in earlier stages when macrocytosis is absent

Therefore, it is not recommended to add ramucirumab to cisplatin plus fluoropyrimidine chemotherapy as first-line therapy

doi: 10.1126/science.abd4570 95 DoykovIHllqvistJGilmourKCGrandjeanLMillsKHeywoodWE