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By inhibiting NNMT, 5-Amino-1MQ prevents the methylation of nicotinamide, which thus remains available for recycling to NAD+ via the salvage pathway

You can read more about the link between mitochondrial dysfunction and neurodegenerative disease in the BMG LABTECH blog Mitochondrial dysfunction and neurodegenerative disease

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Understanding these mechanisms helps clinicians determine whether the elevation is benign or indicative of significant pathology