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Zou, Z., Ohta, T., Miura, F

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In this context, it has been observed that PHDs can be inhibited by fumarate leading to the stabilisation of HIF1 and HIF2 even in normoxia, a phenomenon known as pseudohypoxia [61, 62], and the activation of HIF-associated signalling cascades such as cell growth, angiogenesis, cell survival, migration, and metastasis [63]