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Mitochondrial dysfunction in rheumatoid arthritis

The transition states require that the partial double bond be broken, so that the activation energy is roughly 80 kJ/mol (20 kcal/mol)

The role of exercise in the treatment plan is crucial, and numerous studies show that the best results are obtained after 1224 weeks, and clinical data support the need to continue these combined interventions consistently for at least 8 weeks (114)