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In the univariate model, IGF-1 concentration was associated with age ( p = 0.017), GAD-7 score ( p = 0.005), PSQI score ( p = 0.003), and stage N3 time ( p = 0.007)

A total of 1189 therapeutic targets for DN treatment were identified from DisGeNET, SymMap, and TTD (Figure 1A) (Supplementary Table S7)