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aKG possesses a strong affinity for reactive oxygen species (ROS) released from the mitochondria, especially hydrogen peroxide, which it reacts with as a result of the conversion of succinate, carbon dioxide, and water, subsequently leading to its elimination [145]

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They often involve certain devices and constituents like peel, LED therapy, microcurrents, microdermabrasion, Photorejuvenation, and more

These reactions typically resolve within 24-48 hours

Thus, under normal circumstances, there is no relevant apoptosis after an APAP overdose in mice [42] or human livers [45, 46]