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Similarly, intestinal toxicity manifested as transmural necrosis in the jejunum and ileum in the saline group, while these injuries were consistently prevented by peptide treatment

[27] Other coenzymes, flavin adenine dinucleotide (FAD), biotin, and lipoamide, for instance, are tightly bound

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Years later, with additional clinical information available, Lutz came up with the suggestion that Beppu's group must have used serum/plasma from patients with one of the many autoimmune diseases that are characterized by anti-neutrophil cytoplasmic antibodies (ANCA) (Lutz, 2012)