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An additional unusual feature of trabectedin, not found in several bifunctional alkylating agents, is that absence of the p53 tumor suppressor activity increases antitumor activity about threefold

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b)The slope of the kinetic reaction

- Nausea or stomach upset (common with oral supplements) - Mild skin rashes or itching (possible with topical use) - Temporary bloating or cramping These are usually mild and subside when dosage is adjusted or discontinued

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