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The cells were incubated in 6-well plates (2 mL/well) at a density of 150,000 per well for 24 h, followed by treatment with test compounds with or without cisplatin (1 M) for 48 h

What are the benefits of taking Glycine and NAC separately

Oxidative stress induced by non-anthracycline chemotherapeutic agents Aside from DOX, non-anthracycline chemotherapeutic agents, such as cyclophosphamide (CyC) and cisplatin (CP), cause cardiotoxicity by inducing mitochondrial dysfunction, leading to ETC damage, oxidative phosphorylation, decreased antioxidant enzyme levels and antioxidant capacity, increased ROS, activate Nrf2 and induce apoptosis (77)

Reconstitution mixes the freeze-dried peptide powder with bacteriostatic (BAC) water to create an injectable solution

Statements Author contributions WL: Conceptualization, Data curation, Formal Analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing original draft, Writing review and editing