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Why the Glutathione Index Is the Best Indicator of Brain Oxidative Stress The GSH/GSSG ratio reflects the activity of the enzyme glutathione reductase which is responsible for the transformation of GSSG (used, oxidised) to GSH (the reduced or fully loaded form that acts as a radical scavenger)

J Chromatogr, B: Anal Technol Biomed Life Sci 1225:123755 Hassanein SM, Deifalla SM, El-Houssinie M, Mokbel SA (2016) Safety and efficacy of cerebrolysin in infants with communication defects due to severe perinatal brain insult: a randomized controlled clinical trial

This damage is exacerbated by increased lipid peroxidation and mutations in NADPH oxidase, which impair the bodys antioxidant defences (Reference Kochman, Jakubczyk and Bargiel3)

Effect of organic selenium supplementation on the antioxidant status, immune response, and the relative expression of IL-2 and IFN- genes in ewes during the hot season