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Sperk G, Schwarzer C, Heilman J, Furtinger S, Reimer RJ, et al

Further, increased Nrf2 levels promote the expression of HO-1, superoxide dismutase (SOD), and glutathione (GSH) and decrease that of malonic dialdehyde (MDA) (Chang et al., 2024), simultaneously, Nrf2 negatively regulates the activation of LPS-induced NF-B signaling, inhibits the activity of the NF-B pathway, and suppresses NLRP3 inflammatory vesicles (Xie et al., 2023

For this reason, researchers sometimes refer to glutathione as the detox molecule. 12 Lu SC

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The decreased ratio of [NAD + ]/[NADH] during high glycolysis activity results in decreased SIRT1-mediated deacetylation of histones in muscle stem cells 21