The vulnerability of a recipient to fungal infection is governed by several contributors, mainly immune flaws caused by underlying disorders necessitating an organ transplant (167, 168), organ transplanted type, complications associated with surgery (152, 160, 167), metabolic changes, net state of immunosuppression, infections by viruses, loss of renal function and supplementary therapy to manage graft rejection (152, 165, 169)
Disruption of the murine MRP (multidrug resistance protein) gene leads to increased sensitivity to etoposide (VP-16) and increased levels of glutathione
Subjects treated with ALCAR and controls were matched 1:1 by sex, age at diagnosis ( 5 years), site of onset (spinal/bulbar), and time from diagnosis to baseline ( 3 months)
We have previously identified a compound YMU1, an inhibitor of thymidylate kinase (TMPK), which increased doxorubicin sensitivity of cancer cells by causing DNA repair toxicity 19,20
Virtually all cells in the body contain an abundance of glutathione, known as the bodys master antioxidant. Glutathione is involved in essential cellular functions, including protecting the cell from oxidative stress, and is vital to overall health and wellness. When glutathione levels are suboptimal or deficient, it affects health throughout the body, resulting in symptoms and increased risk for chronic diseases
