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Description

Dorling, Leila

10.1161/ATVBAHA.111.232058 160 KondrikovD.FonsecaF

Strengths of this study include the wide reach of the survey, large dataset, global population, and use of the visual aid tool provided in the survey for accurate self-assessment of disease severity

Although the events that lead from IOP elevations to ganglion cell damage are not well defined, a body of recent work has pointed at mechanotransducing TRPV4, piezo and TREK-1 channels and immune mechanisms as key pressure targets in trabecular meshwork, ciliary body, retinal ganglion, endothelial cells and glia