Nucleotide excision repair (NER) eliminates a series of helix-distorting lesions that are mostly induced by UV irradiation, 76,77 whereas base excision repair (BER) primarily acts on the modification of oxidative bases, 78,79 and mismatch repair (MMR) scans for incorrectly inserted nucleotides during replication
a) Early localized Lyme disease (within a month) symptoms include fever, arthralgias, myalgias, headache, the presence of a single, localized skin lesion known as erythema migrans (EM) b) Early disseminated Lyme disease (less than 3 months) symptoms such as fatigue and general weakness, cutaneous signs, typical cardiac complications include atrioventricular block, tachyarrhythmias, myopericarditis and myocardial dysfunction, neurological symptoms are aseptic meningitis, radiculopathy, encephalopathy, cranial neuropathy (especially facial nerve palsy), monomeutitis multiplex, subtle cognitive difficulties, motor and sensory radiculoneuropathy
Wu X, Zhang L, Miao Y, Yang J, Wang X, Wang CC, Feng J, Wang L (2019) Homocysteine causes vascular endothelial dysfunction by disrupting endoplasmic reticulum redox homeostasis
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