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A more recent study in human participants using carbon-13 magnetic resonance spectroscopy (13^C-MRS) and subanesthetic doses of ketamine showed that the glutamate/glutamine ratio (synaptic strength) was increased in correlation with a measure of the dissociative state, suggesting that prefrontal cortex glutamate release follows use of ketamine ( Lower doses of ketamine, on the other hand, have been used in models of chronic pain which highlight the role of PKC in modulating the adaptive response of the organism to nociception

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