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Bullous rash reactions including Stevens-Johnson syndrome and Lyells syndrome (toxic epidermal necrolysis), exfoliative dermatitis, erythema multiforme, and anaphylactoid reactions including anaphylactic shock, angioedema, and tongue or laryngeal edema have been reported through the postmarketing surveillance program

Effects of vitamin B12 on methotrexate hepatotoxicity: Evaluation of receptor-interacting protein (RIP) kinase

Often, patients see longer-lasting results with subsequent treatments

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33,34,35,36,37 One study suggests that length of time from diagnosis of cognitive impairment is important for response rate, in that patients who had experienced symptoms for less than 12 months improved on B12, whilst those with symptoms for more than 12 months continued to decline