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In some settings, improvements in oxidative stress markers were not accompanied by proportional reductions in inflammatory cytokines, indicating that antioxidant effects may not fully account for immunometabolic modulation (Zakaria et al., 2025)

Since glutathione levels are lower from conception to infancy, children are even more at risk of oxidative stress

Other studies have confirmed these findings by showing that IL6 and TNF are elevated following an 88hour period of wakefulness (160) and that the nighttime rise of IL6 levels is delayed during partial sleep deprivation (161)

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These free radicals then cause further damage to the mitochondrial DNA and lipid membranes, leading to even less energy production