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If a vial was left out overnight, the peptide may have lost meaningful potency

We further performed doxycycline-inducible expression of oxygen-dependent NADPH oxidase (NOX) in the cytosol (TPNOX) or mitochondria (mitoTPNOX) to deplete compartmentalized NADPH, as described previously 30 , and tested the cellular sensitivity to glucose starvation (Extended Data Fig

In general, G6PD mutations are position-specific and may cause severe deficiency if they abrogate functional domains of the protein, such as dimerization and alteration of the substrate binding interface

Most AuNPs designs are optimized for animal models that poorly mimic the immune responses, tumor heterogeneity, or clearance mechanisms observed in humans

Thus, by studying the metal-protein interaction of metalloprotein, one can elucidate the role of metals in biological systems