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Physiology and endocrine changes underlying human lactogenesis II

DNA Damage: from threat to treatment

In vitro studies have shown retinoic acid (RA) causes radiosensitization in human tumor cell lines at concentrations which do not cause cellular toxicity

However, due to the absence of centrioles, the resultant spindle morphology is reduced in size, and the characteristic astral microtubules at the poles are absent, contributing to the increased instability of spindle assembly in human oocytes