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Another HLA risk allele identified in genome-wide association studies is the rs2476601 variant in the PTPN22 gene, which is associated with an increased risk of DILI from multiple drugs

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The evolution from single to triple agonism The trajectory of incretin-based obesity pharmacotherapy shows a clear pattern of increasing complexity and efficacy: First generation (single agonist): Liraglutide (Saxenda) and semaglutide (Wegovy) target GLP-1 only

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This peptide stimulates nitric oxide synthase generation and therefore offers gastric cytoprotection