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3 In addition, LPALPAR4/6 signaling through the G12/13-Rho-ROCK pathway activates YAP and transcriptional coactivator with PDZ-binding motif (TAZ) transcription factor, which drives delta-like ligand 4 (DLL4) expression via the -catenin and Notch intracellular domain (NICD) pathways, contributing to CNS angiogenesis during development