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Methods: In this population-based cohort study, we identified all patients with an ICD-10 code for MASLD in Swedish healthcare registers 2002-2020 (n=13,099) and matched them with 10 controls from the general population for age, sex, municipality, and calendar year (n=118,884)

PC 16:0_18:1, one of the most abundant phospholipids in the brain with proven anti-ferroptotic activity 25 , was depleted significantly in the CMD group

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ATP induces disruption of tight junction proteins via IL-1 beta-dependent MMP-9 activation of human blood-brain barrier in vitro