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Likewise, due to the large presence in human fetuses and adult tissues (in situ hybridization and immunostaining) [14], the concept holds a regulatory physiologic role in bodily functions [14], also based on similar beneficial effects in other species (i.e., birds [73] and insects [74,75,76])

None of the patients had signs of urinary infection, nor were any treated with any oral drugs or intravesical instillations 6 months prior to intravesical injection of BPC-157

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Furthermore, to understand the mechanism underlying nerve regeneration, additional research could investigate the expression of regenerative factors at the treatment site