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One study found the following rates of subclinical hypothyroidism after 12 months of using various anti-seizure medications: 28% in valproate, 21.4% in oxcarbazepine, 18.2% in phenobarbital, 13.9% in carbamazepine, and 0% in levetiracetam groups. Another study, published in Diabetes, Obesity and Metabolism , found that a ketogenic diet resulted in lowered T3 levels and raised reverse T3 levels in healthy subjects

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The Krebs or TCA cycle with its electron transport chain ETC also requires activated B2 and B3

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