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The in vivo passage was responsible for the modification in key phase-variable genes

The induction of tumor suppressor agents that act and stimulate apoptosis, such as initiator caspases (8 and 9), and effector caspase (3), p38, p53 and JNK1/2, and suppression of the expression or activity of apoptosis inhibitors such as Survivin and Bcl-2 have been discussed in various cellular studies (Agarwal et al., 2013)

Now at four months, some of the more shallow discoloration is nearly gone, and the deeper spots have definitely lightened

Epigenetic IVD tests for personalized precision medicine in cancer