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Additional molecular targets being investigated include MMPs, ADAMTS enzymes, and neurotrophic factors that contribute to pain amplification and extracellular matrix breakdown [10]

Various small molecule compounds regulate the expression and activity of MMPs through different molecular mechanisms, thus inhibiting the invasive behavior of GBM

Adverse effects of the usage of indomethacin are headache, dizziness, lightheadedness and gastrointestinal disturbances such as nausea, loss of appetite, vomiting, epigastric distress, abdominal pain and diarrhea.5 Gastrointestinal bleeding may also result from its use

The challenges presented by the body's partial clearance mechanisms (such as the mononuclear phagocytes found in the spleen and liver or the initial chemical alterations that occur in the liver) affect the elimination or metabolic activity of effective pharmaceutical substances and contribute to the indiscriminate distribution of drugs

The significance of differences between genotypes was tested by t test (GraphPad Prism)