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Aladdin, China) was administered to mice by adding to drinking water for 16 weeks, and was changed to fresh twice a week

Bioorg Med Chem Lett 2007;17:4614

Studies using HFDinduced steatosis and methioninecholine-deficient (MCD) dietinduced steatohepatitis male C57BL / 6 J mice models show that aerobic exercise markedly reduces LDmitochondria contacts by decreasing hepatic PLIN5 expression and upregulates hepatic Mfn-2 to reshape the lipid composition of mitochondrial membranes [93]