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Notably, significant fluorescence was retained in the liver at 48 h, aligning with the livers role in liposome clearance

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As promiscuous protein binding of ASOs often leads to unfavorable clinical properties 9 , a better understanding of this, also in terms of structure 48 , has led 14,49 and will likely lead to further improvements in the clinics

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Inactivation or loss of Rubisco would reduce V cmax while a reduction in J max is associated with the diminution of key regulatory enzymes such as SBPase and FBPase in the Calvin cycle 36,37