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In evidence-based care, clinicians often slow titration or hold at an intermediate step when side effects kick up, GI comorbidities exist, or drug interactions complicate tolerability

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Acknowledgements We gratefully acknowledge the support of the Center for Biological Imaging, Core Facilities for Protein Science at the Institute of Biophysics (IBP), Chinese Academy of Sciences (CAS), and the Institute of Physics, CAS & Beijing Branch of Songshan Lake Materials Laboratory, for providing access to cryo-EM data collection

Conclusion: The findings emphasise the importance of time adjustments in future prognostic models for stroke severity, particularly for AIS