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Furthermore, no significant difference in survival rates was observed between the metabolic groups, suggesting that the clinical significance of this classification is limited and requires further validation

Additionally, GH receptor (GHR) is widely expressed in hypothalamic areas implicated in energy balance regulation, including the arcuate nucleus (ARH) 11

doi: 10.1016/j.neuroscience.2022.01.007 6 ArigaT.WakadeC.YuR

Based on cross-study comparisons, the weight-normalized, apparent total body clearance was 33% greater and the elimination half-life was 33% shorter in this pediatric population than in adults

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