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Regional Disciplinary Medical Board: vitamin B12 cannot be overdosed In 2009, the Regional Disciplinary Medical Board in Eindhoven stated very clearly that an overdose is not possible: There can be no question of an overdose of hydroxocobalamin, as the excess is excreted in urine by the kidneys and therefore cannot accumulate in the body

Third, stimulation of glycosaminoglycan and proteoglycan synthesis

Although there were no statistically significant differences between MOD and SEV groups regarding the occurrence of clinical complications, the outcomes were significantly worse for patients in the SEV group, with longer total hospitalization time ( P = 0.0132) and more frequent deaths ( P = 0.0036) ( Table 1 )

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