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Human data remains limited , with insufficient long-term safety information

Current evidence supports a multifactorial etiology in which more than 90 susceptibility loci, rare monogenic variants (e.g., LRRK2, SNCA, PRKN, and PINK1) and environmental toxicants (pesticides, heavy metals, and solvents) converge on three inter-related pathological hallmarks: oxidative stress, mitochondrial dysfunction and chronic neuroinflammation

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As a consequence of these challenges to utilising human tissue in cataract research, animal models have been used to investigate the underlying mechanisms of cataract formation (26) following a range of cataractous insults

Tirzepatide the approved label starts at 2.5 mg once weekly and escalates in 2.5 mg steps at intervals of at least four weeks, to a maintenance dose of up to 15 mg once weekly