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Mayo Clin Proc (2008) 83(5):56671

B vitamin therapy for homocysteine: renal function and vitamin B12 determine cardiovascular outcomes

12 Pathophysiology and signaling pathways involved T2D, usually accompanied by other manifestations of MDS, is a complex metabolic disease with multiple underlying mechanisms not fully understood, while IR and cell dysfunction are two core pathophysiological mechanisms 13,14 (Fig