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Two clinical trials are ongoing to support the utility of this potential combination pharmacotherapy in treating people with overweight and obesity

Cagrilintide, a long-acting amylin analogue: pharmacology and receptor activity

Even when late-stage data look strong, the FDA still reviews efficacy, adverse events, manufacturing, labeling, contraindications, drug interactions, and risk-management requirements

On the other hand, strict glucose control does not limit or improve the damage caused by diabetes and its comorbidities to the CNS [17, 18] as the impact of insulin resistance, obesity, and diabetes on the CNS begins very early in the natural history of the disease [19]