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153 Thus, whether these observations constitute examples of bona fide on-target resistance or rather reflect the critical role of mitochondria (and in particular of the PTPC) in CDDP-elicited cell death, hence constituting examples of post-target resistance, remains an open conundrum

Lancet 368:387403

J Biol Chem 247: 5123-5513

Nevertheless, its antidepressant effects have been demonstrated in mice via abdominal injection, suggesting that its pharmacokinetic propertiesparticularly regarding absorption and brain distributiondeserve further investigation (Zhou Y