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Discussion The primary objectives of this study were to investigate the role of AMY 1 R and AMY 3 R in mediating the metabolic effects of amylin and calcitonin receptor agonists, specifically cagrilintide and sCT, and to explore potential differences in their mechanisms of action at the in vivo and ex vivo levels

In the primary analysis using the trial product estimand, which evaluated participants who adhered to treatment, bodyweight decreased progressively in all active treatment groups over the 26-week period, without clear evidence of reaching a plateau

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More dermal papilla cells means a stronger growth signal being sent to the hair follicle