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If your reactions cluster around the same quadrant or follow a dose increase, the failure mode is concentrated exposure, not random bad luck

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In animal reproduction studies, there was no evidence of adverse developmental outcomes when fondaparinux sodium was administered to pregnant rats and rabbits during organogenesis at doses 32 times and 65 times, respectively, the recommended human dose based on body surface area

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On follow-up at 6 months, the patient presented mucocutaneous jaundice, asthenia, and dyspnea at rest