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This value is consistent with the endogenous brain-to-serum concentration ratio of CT [3], suggesting that the BBB functions as a major pathway for supplying CT to the brain from the circulating blood

Stimulation of NMDARs (75) induces iron deposition in cells by activating the GTP (guanosine triphosphate) -binding protein Dexrasl, which contributes to activate the metal ion transporters, including the divalent metal transporter-1 (DMT1) (76) found that intravitreal injection of NMDA led to Fe 2+ accumulation in RGCs and triggered their apoptosis, resulting in a lower number of cells 7 days after injection

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This validates the hypothesis that ferroptosis plays a critical pathological role after a hemorrhagic stroke