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In fact, it is the number one reason people are so interested in this little amino acid these days

In High Dose In-Vitro Models, Curcumin Can Cause Cytotoxicity and DNA Damage At high doses it is suggested that curcumin may actually induce ROS, leading to DNA damage [119]

The abnormal extracellular matrix and tumor vasculature surrounding tumor cells result in uneven drug distribution within the tumor, thereby reducing the effective drug concentration ( CAFs play a critical role in tumor progression and drug resistance by secreting growth factors and cytokines that promote tumor cell proliferation and migration

Homogenization of 0.5 g of tissues was achieved using a 50 mM tris buffer solution with a pH of 10.0, followed by centrifugation for 20 min at 13,000 rpm

J Am Coll Cardiol 57(5):577585