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Foods containing ornithine The amino acid is mainly found in animal-based foods, while plant sources only contain trace amounts

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(2019) 28:262033.e4

FLT3 inhibitor therapy for patients with myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML): impact on survival according to FLT3 status

doi: 10.1097/00000478-199003000-00002 5 GoldsteinMMCaseyMCarneyJABassonCT

Therefore, although CRBN shows low affinity for dHTC1 and no detectable binding to ENL up to a concentration of 1 M, the stable, preformed ENL:( S )-dHTC1 complex can cooperatively engage CRBN with high apparent affinity to induce stereochemistry-dependent ENL degradation