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What is thymosin beta 4: Thymosin beta-4 (T4) is a peptide produced in most tissues of the body (except red blood cells)

Further preclinical and clinical studies could provide evidence for berberines clinical utility in attenuating secondary brain injury after TBI

Conflicts of interest: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest

The injection is administered intramuscularly, typically in the upper arm or glute, and usually takes just a few seconds

Interestingly, the anti-apoptotic protein Bcl-2 binds to mutant SOD1 and aggregates in spinal cord mitochondria from patients and a mouse model of ALS, suggesting that mutant SOD1 may be toxic by depleting motor neurons of this anti-apoptotic protein (Pasinelli et al., 2004)