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In insulin-responsive tissues, the equilibrium between MI and its epimer D-chiro-inositol (DCI) is important because insulin promotes the epimerase-mediated conversion of MI into DCI, which is then incorporated into GPI-anchored proteins and released as DCI-IPGs following insulin stimulation (137)

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Titration over several weeks has multiple benefits: Better tolerability: The body adapts gradually to the peptide

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Altogether, these proinflammatory changes in vascular homeostasis are known to promote proatherogenic accumulation of both inflammatory leukocytes and LDL in the vascular wall 36 (Fig