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Myocardial infarction models have documented reduced infarct sizes and improved cardiac function when GHK-Cu is administered shortly following coronary occlusion, effects attributed to enhanced angiogenesis, reduced inflammatory damage, and improved matrix remodeling in healing myocardium

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186 With respect to the specificity of Cu chelators, the use of trientine has been shown to inhibit the expression of IL-8 and exhibits anti-tumor effects in hepatocellular carcinoma