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Downregulation of CAV1 reduces the levels of GPX4 and FTH1, increases ROS and Fe 2+ concentrations, promotes ferroptosis, and reduces cancer cell migration and invasion, 171 suggesting that the regulatory pathways of CAV1 and ferroptosis may be potential targets for diagnosis and combination therapy strategies in patients with HNSCC

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As emerging platforms such as SERS-based sensors, electrochemical nanomaterial arrays, and MALDI mass spectrometry imaging continue to mature, researchers will gain even greater precision in mapping intracellular glutathione dynamics across complex biological systems